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Hemorrhage. Increased PT/INR due to interaction between coumarin anticoagulants and Casodex. Serious bleeding reported. [see Warnings and Precautions (5.2)]

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Caution should be exercised when prescribing Casodex with other drugs which may inhibit drug oxidation e.g. cimetidine and ketoconazole. In theory.this could result in increased plasma concentrations of Casodex which theoretically could lead to an increase in side effects.

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