Reproductive and developmental studies in animals demonstrated that diclofenac sodium administration during organogenesis did not produce teratogenicity despite the induction of maternal toxicity and fetal toxicity in mice at oral doses up to 20 mg kg day approximately 5 times the maximum recommended human dose mrhd of voltaren gel based on bioavailability and body surface area bsa comparison , and in rats and rabbits at oral doses up to 10 mg kg day approximately 5 and 10 times the mrhd based on bioavailability and bsa comparison .

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There is no consistent evidence that concurrent use of aspirin mitigates the increased risk of serious CV thrombotic events associated with NSAID use. The concurrent use of aspirin and an NSAID.such as diclofenac.increases the risk of serious gastrointestinal (GI) events (see WARNINGS. Gastrointestinal Bleeding.Ulceration.And Voltaren gel no prescription ).

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Elderly patients.compared to younger patients.are at greater risk for NSAID-associated serious cardiovascular.gastrointestinal.and/or renal adverse reactions. If the anticipated benefit for the elderly patient outweighs these potential risks.start dosing at the low voltaren gel no prescription of the dosing range.and monitor patients for adverse effects (see WARNINGS. Cardiovascular Thrombotic Events.Gastrointestinal Bleeding.Ulceration.and Perforation.Hepatotoxicity.Renal Toxicity and Hyperkalemia.PRECAUTIONS. Laboratory Monitoring ).

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