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The onset of lactic acidosis often is subtle and accompanied by nonspecific symptoms (eg.malaise.myalgias.respiratory distress.increasing somnolence.nonspecific abdominal distress). with marked acidosis.hypothermia.hypotension.and resistant bradyarrhythmias may occur. patients should be instructed regarding recognition of these symptoms and told to notify their physician immediately if the symptoms occur. metformin should be withdrawn until the situation is clarified. serum electrolytes.ketones.blood glucose.and.if indicated.blood pH.lactate levels.and even blood metformin levels may be useful.

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begining on my first cycle after being on metformin for one month at 1000mg i took letrozol and responded well.

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